The purpose of this paper is to highlight the determinants of inflation in Cameroon from 1970 to 2015. The study uses quantitative approaches, mainly ordinary least squares and the model of error correction. The results revealed that in long run and short run, inflation is positively influenced by economic growth and volume of money. The results also stressed that household consumption expenditures, exportations of goods and services, financial liberation and devaluation positively impact inflation in Cameroon, while the importations of goods and services negatively influences inflation of the country. The results of this study mainly indicate that the control of price can reduce the excess of profits gained by firms and reduce importation of goods and services that also import international inflation in the country.